Tumor necrosis factor as an activator of human granulocytes. Potentiation of the metabolisms triggered by the Ca2+-mobilizing agonists.

@article{Yuo1989TumorNF,
  title={Tumor necrosis factor as an activator of human granulocytes. Potentiation of the metabolisms triggered by the Ca2+-mobilizing agonists.},
  author={Akira Yuo and Seiichi Kitagawa and Ichir{\^o} Suzuki and Akio Urabe and Tetsuro Okabe and Mikiyoshi Saito and Fumimaro Takaku},
  journal={Journal of immunology},
  year={1989},
  volume={142 5},
  pages={
          1678-84
        }
}
TNF stimulated superoxide (O2-) release directly in human granulocytes in a dose-dependent manner (1 to 1000 U/ml), although its potency was weak. TNF-induced O2- release was inhibited by cAMP agonists or ionomycin, and was not accompanied with an increase in cytoplasmic free Ca2+ [( Ca2+]i) and membrane potential changes (depolarization). These findings indicate that neither Ca2+ mobilization nor membrane depolarization is required for TNF-receptor-mediated cell activation. The pretreatment of… CONTINUE READING

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Shock, Sepsis, and Organ Failure

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