Tumor necrosis factor as a therapeutic target of rheumatologic disease.

@article{Ackermann2007TumorNF,
  title={Tumor necrosis factor as a therapeutic target of rheumatologic disease.},
  author={Christoph Ackermann and Arthur J Kavanaugh},
  journal={Expert opinion on therapeutic targets},
  year={2007},
  volume={11 11},
  pages={1369-84}
}
TNF-alpha is a crucial pro-inflammatory and immunoregulatory cytokine that is central to the pathogenesis of various inflammatory and autoimmune conditions. A number of controlled trials have shown effectiveness for TNF-alpha inhibitors in several diseases, in particular rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and Crohn's disease. These agents may also be useful in additional autoimmune conditions. The introduction of TNF-alpha inhibitors has revolutionized the… CONTINUE READING