• Biology, Medicine
  • Published in Journal of andrology 1990

Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro.

@article{Warren1990TumorNF,
  title={Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro.},
  author={Dwight W. Warren and Vijaya Pasupuleti and Yin Lu and B W Platler and Richard Horton},
  journal={Journal of andrology},
  year={1990},
  volume={11 4},
  pages={
          353-60
        }
}
The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied. In one set of experiments, testis cells from adult (90-day-old) rats were enzymatically dispersed. In another set of experiments, the dispersed testis cells were placed on a Percoll density gradient and were centrifuged to yield purified (greater than 85%) Leydig cells. Both whole testis cells and… CONTINUE READING

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