Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro.
@article{Warren1990TumorNF, title={Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro.}, author={D. W. Warren and V. Pasupuleti and Y. Lu and B. W. Platler and R. Horton}, journal={Journal of andrology}, year={1990}, volume={11 4}, pages={ 353-60 } }
The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied. In one set of experiments, testis cells from adult (90-day-old) rats were enzymatically dispersed. In another set of experiments, the dispersed testis cells were placed on a Percoll density gradient and were centrifuged to yield purified (greater than 85%) Leydig cells. Both whole testis cells and… CONTINUE READING
Topics from this paper
87 Citations
Tumor necrosis factor alpha inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action.
- Biology, Medicine
- Endocrinology
- 1991
- 61
The effect of testicular macrophages and interleukin-1 on testosterone production by purified adult rat Leydig cells cultured under in vitro maintenance conditions.
- Biology, Medicine
- Endocrinology
- 1993
- 75
Cytokine secretion by macrophages in the rat testis.
- Biology, Medicine
- Biology of reproduction
- 1995
- 149
- PDF
The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis.
- Biology, Medicine
- Endocrinology
- 1993
- 119
- PDF
Secretion of tumor necrosis factor alpha by testicular macrophages.
- Biology, Medicine
- Journal of reproductive immunology
- 1993
- 33
Effects of interleukin-6, interleukin-2, and tumor necrosis factor alpha on transferrin release from Sertoli cells in culture.
- Biology, Medicine
- Endocrinology
- 1991
- 65
Tumor necrosis factor-alpha antagonizes follicle-stimulating hormone action in cultured Sertoli cells.
- Biology, Medicine
- Endocrinology
- 1993
- 44
Recombinant murine tumor necrosis factor-alpha inhibits cholesterol side-chain cleavage cytochrome P450 and insulin-like growth factor-I gene expression in rat Leydig cells
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 1994
- 31
References
SHOWING 1-10 OF 27 REFERENCES
Inhibitory actions of interleukin-1 beta on steroidogenesis in primary cultures of neonatal rat testicular cells.
- Biology, Medicine
- Acta endocrinologica
- 1989
- 53
Interleukin-1 inhibits Leydig cell steroidogenesis in primary culture.
- Biology, Medicine
- Endocrinology
- 1988
- 204
Stimulatory effects of epidermal growth factor on steroidogenesis in Leydig cells
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 1986
- 78
Insulin augmentation of testosterone production in a primary culture of rat testicular cells.
- Biology, Medicine
- Biology of reproduction
- 1982
- 61
- PDF
Interleukin-1 inhibits luteinization of porcine granulosa cells in culture.
- Biology, Medicine
- Endocrinology
- 1988
- 131
Insulin-like growth factor-I augments gonadotropin-stimulated androgen biosynthesis by cultured rat testicular cells
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 1987
- 77
The effect of tumor necrosis factor/cachectin on follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells.
- Biology, Medicine
- Biochemical and biophysical research communications
- 1988
- 93
Interleukin-1 inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro.
- Biology, Medicine
- Biochemical and biophysical research communications
- 1987
- 105
Tumor necrosis factor alpha alters follicular steroidogenesis in vitro.
- Biology, Medicine
- Endocrinology
- 1988
- 91