Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability.

@article{Royall1989TumorNF,
  title={Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability.},
  author={James A Royall and Roger L. Berkow and Joseph S. Beckman and Mark Cunningham and Sadis Matalon and Bruce A. Freeman},
  journal={The American journal of physiology},
  year={1989},
  volume={257 6 Pt 1},
  pages={L399-410}
}
Endotoxic shock is associated with acute vascular endothelial injury resulting in edema. Tumor necrosis factor (TNF) and interleukin 1 (IL-1) are cytokines produced by endotoxin-stimulated mononuclear phagocytes that are potential mediators of endotoxic shock. In this study, we investigated the effects of TNF and IL-1 alpha on vascular endothelial cell permeability in vitro. The movement of radiolabeled macromolecules of different sizes (57Co-vitamin B12, 125I-cytochrome c, and 131I-albumin; 6… CONTINUE READING

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