Tumor necrosis factor and alcoholic liver disease.

  title={Tumor necrosis factor and alcoholic liver disease.},
  author={C J Mcclain and Shirish Barve and Ion V Deaciuc and Daniell B. Hill},
  journal={Alcoholism, clinical and experimental research},
  volume={22 5 Suppl},
Increased levels of hepatic and serum tumor necrosis factor (TNF) have been documented in animal models of alcoholic liver disease and in human alcoholic liver disease. This dysregulated TNF metabolism has been postulated to play a role in many of the metabolic complications and the liver injury of alcoholic liver disease. One potential therapy for alcoholic liver disease may be agents that downregulate TNF production or block TNF activity. Indeed, agents such as prostaglandins and… CONTINUE READING


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Current concepts in the pathogenesis of alcoholic liver injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001
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