Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.

@article{Papaharalambus2005TumorNF,
  title={Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.},
  author={Christopher A Papaharalambus and Waseem Sajjad and Aazrum Syed and Chen Zhang and Martin O. Bergo and Robert W. Alexander and Mushtaq Ahmad},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 19},
  pages={18790-6}
}
We have previously demonstrated that both isoprenylcysteine carboxylmethyltransferase (ICMT) and one of its substrates, the RhoGTPase Rac1, are critical for the tumor necrosis factor alpha (TNF alpha) stimulation of vascular cell adhesion molecule-1 expression in endothelial cells (EC). Here, we have shown that ICMT regulates TNF alpha stimulation of Rac1 activity. TNF alpha stimulation of EC increased the membrane association of Rac1, an event that is essential for Rac1 activity. ICMT… CONTINUE READING