Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells.

Abstract

OBJECTIVE Fas-mediated apoptosis is observed in synoviocytes of patients with rheumatoid arthritis (RA), but not in those of patients with osteoarthritis (OA). The present study was conducted to elucidate the mechanisms that initiate induction of Fas-mediated apoptosis in RA synoviocytes. METHODS Cultured OA synoviocytes, which are insensitive to Fas… (More)

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