Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage.

@article{Westacott1994TumorNF,
  title={Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage.},
  author={C I Westacott and Roger Atkins and P. A. Dieppe and Christopher J. Elson},
  journal={The Journal of rheumatology},
  year={1994},
  volume={21 9},
  pages={1710-5}
}
OBJECTIVE To determine whether the previously observed enhanced susceptibility of osteoarthritic (OA) cartilage to tumor necrosis factor-alpha (TNF-alpha) induced degradation could be due to differences in receptor expression. METHODS Using specific monoclonal antibodies flow cytometry was used to identify and quantify 2 TNF-alpha receptors on the surface of chondrocytes isolated from human articular cartilage. RESULTS The proportion of chondrocytes expressing p55 TNF-alpha receptor was… CONTINUE READING

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