Tumor necrosis factor alpha promoter polymorphisms and liver abnormalities of homozygotes for the 845G>A(C282Y) hereditary hemochromatosis mutation.

@article{Beutler2002TumorNF,
  title={Tumor necrosis factor alpha promoter polymorphisms and liver abnormalities of homozygotes for the 845G>A(C282Y) hereditary hemochromatosis mutation.},
  author={Ernest Beutler and Terri Gelbart},
  journal={Blood},
  year={2002},
  volume={100 6},
  pages={
          2268-9
        }
}
Although many opinions have been offered regarding the penetrance of hemochromatosis in homozygotes for the 845G>A (C282Y) HFE mutation, a controlled study has shown that very few of these individuals develop clinical disease.[1][1] Clearly, the homozygous state is a necessary but not sufficient 

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