Tumor necrosis factor-alpha production of influenza A virus-infected macrophages and potentiating effect of lipopolysaccharides.

@article{Nain1990TumorNF,
  title={Tumor necrosis factor-alpha production of influenza A virus-infected macrophages and potentiating effect of lipopolysaccharides.},
  author={Marianne Nain and Frank Hinder and Jinmei Gong and Anskar Schmidt and Ariane Nunes Bender and H. N. Sprenger and Diethard Gemsa},
  journal={Journal of immunology},
  year={1990},
  volume={145 6},
  pages={
          1921-8
        }
}
Influenza A virus infections are commonly associated with symptoms that suggest involvement of TNF-alpha. In this study, we exposed human monocytes, rat alveolar macrophages, and murine PU5-1.8 macrophages to influenza A virus, strain Puerto Rico 8. We observed a productive infection that was accompanied by TNF-alpha mRNA accumulation, TNF-alpha release and subsequent cell death. TNF-alpha production was dependent on exposure to live virus, in contrast to IFN release that was also induced by UV… CONTINUE READING

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