Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.

@article{Breese1994TumorNF,
  title={Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.},
  author={Emma J. Breese and Colin A. Michie and Steve Nicholls and Simon H. Murch and Christopher J. Williams and Paula Domizio and John A. Walker-Smith and Thomas Macdonald},
  journal={Gastroenterology},
  year={1994},
  volume={106 6},
  pages={1455-66}
}
BACKGROUND/AIMS Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS A sensitive, reverse hemolytic plaque assay was used to determine the frequency of TNF-alpha secreting cells isolated from mucosal biopsy specimens of children with Crohn's disease or ulcerative colitis (UC) and non-IBD controls… CONTINUE READING

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