Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women.

@article{Moffett2005TumorNF,
  title={Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women.},
  author={Susan P. Moffett and Joseph M. Zmuda and Jennifer I Oakley and Thomas J. Beck and Jane A. Cauley and Katie L. Stone and L Y Lui and Kristine E Ensrud and Teresa A. Hillier and Marc C. Hochberg and Phillip Morin and Gary Peltz and Deborah Greene and Steve Cummings},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 6},
  pages={3491-7}
}
TNFalpha is a proinflammatory cytokine that promotes osteoclastic bone resorption. We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteoporosis phenotypes in 4306 older women participating in the Study of Osteoporotic Fractures. Femoral neck bone mineral density (BMD) and structural geometry were measured using dual-energy x-ray absorptiometry and hip structural analysis. Incident fractures were confirmed by physician adjudication of radiology… CONTINUE READING

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