Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.

@article{Gilles1992TumorNF,
  title={Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.},
  author={Peter Gilles and G L Fey and Francis V. Chisari},
  journal={Journal of virology},
  year={1992},
  volume={66 6},
  pages={3955-60}
}
It is well known that several inflammatory cytokines can modulate hepatocellular gene expression in a complex physiological process known as the hepatic acute-phase response. Since hepatitis B virus (HBV) characteristically induces a vigorous lymphomononuclear inflammatory response in the liver during acute and chronic hepatitis, it is possible that hepatocellular HBV gene expression may also be modulated by one or more of the cytokines produced by these cells. Using bacterial… CONTINUE READING

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