Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages.

@article{Silva1995TumorNF,
  title={Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages.},
  author={Jo{\~a}o S. Silva and Glaucia N R Vespa and Marco Antonio Cardoso and J{\'u}lio C. S. Aliberti and Fernando Q Cunha},
  journal={Infection and immunity},
  year={1995},
  volume={63 12},
  pages={4862-7}
}
Cell invasion by Trypanosoma cruzi and its intracellular replication are essential for continuation of the parasite life cycle and for production of Chagas' disease. T. cruzi is able to replicate in nucleated cells and can be killed by activated macrophages. Gamma interferon (IFN-gamma) is one of the major stimuli for the activation of macrophages and has been shown to be a key activation factor for the killing of intracellular parasites through a mechanism dependent upon nitric oxide (NO… CONTINUE READING
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