Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.

@article{Park2010TumorNF,
  title={Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.},
  author={Keigan M. Park and William J. Bowers},
  journal={Cellular signalling},
  year={2010},
  volume={22 7},
  pages={977-83}
}
Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will… CONTINUE READING