Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.

@article{Engelman2000TumorNF,
  title={Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.},
  author={Jeffrey A. Engelman and Anders H. Berg and Roshan Lewis and Michael Phillip Lisanti and Phillip E Scherer},
  journal={Molecular endocrinology},
  year={2000},
  volume={14 10},
  pages={
          1557-69
        }
}
Tumor necrosis factor-alpha (TNFalpha) has been implicated as a contributing mediator of insulin resistance observed in pathophysiological conditions such as obesity, cancer-induced cachexia, and bacterial infections. Previous studies have demonstrated that TNFalpha confers insulin resistance by promoting phosphorylation of serine residues on insulin receptor substrate 1 (IRS-1), thereby diminishing subsequent insulin-induced tyrosine phosphorylation of IRS-1. However, little is known about… CONTINUE READING

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