Tumor necrosis factor-alpha initiated signal transduction in 3T3-L1 adipocytes.

  title={Tumor necrosis factor-alpha initiated signal transduction in 3T3-L1 adipocytes.},
  author={Renu G Jain and Kevin D. Phelps and Phillip H. Pekala},
  journal={Journal of cellular physiology},
  volume={179 1},
Examination of the ability of tumor necrosis factor-alpha (TNF) to activate both the p44/42 and p38 MAP kinase cascades in fully differentiated 3T3-L1 adipocytes indicated a rapid MEK1/2-dependent activation of p44/42 MAP kinase. Use of the MEK1/2 inhibitor PD98059 indicated that this pathway at least in part was responsible for nuclear localization of the transcription factor NF-kappaB. The stress/cytokine-activated p38 MAP kinase was observed to be constitutively active, and its… CONTINUE READING
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