Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans.

@article{RaskMadsen2003TumorNF,
  title={Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans.},
  author={Christian Rask-Madsen and Helena Dominguez and Nikolaj Ihlemann and Thomas Hermann and Lars K{\o}ber and C Torp-Pedersen},
  journal={Circulation},
  year={2003},
  volume={108 15},
  pages={
          1815-21
        }
}
BACKGROUND Inflammatory mechanisms could be involved in the pathogenesis of both insulin resistance and atherosclerosis. Therefore, we aimed at examining whether the proinflammatory cytokine tumor necrosis factor (TNF)-alpha inhibits insulin-stimulated glucose uptake and insulin-stimulated endothelial function in humans. METHODS AND RESULTS Healthy, lean male volunteers were studied. On each study day, 3 acetylcholine (ACh) or sodium nitroprusside (SNP) dose-response studies were performed by… CONTINUE READING

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