Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration.

  title={Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration.},
  author={Josef Stadler and Brandon G. Bentz and Brian G. Harbrecht and Mauricio Di Silvio and R D Curran and Timothy R Billiar and Rosemary Hoffman and Richard L. Simmons},
  journal={Annals of surgery},
  volume={216 5},
Although direct cytotoxicity is a well-established phenomenon of tumor necrosis factor alpha (TNF alpha)-induced tissue damage, the intracellular events leading to cell death are still poorly understood. To study the cytotoxic effects of TNF alpha on normal parenchymal cells, rat hepatocytes were purified and incubated with various concentrations of TNF alpha. Mitochondrial respiration, total protein synthesis, and enzyme release were measured to assess metabolic performance and cell integrity… CONTINUE READING

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