Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.

@article{Wisp1990TumorNF,
  title={Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.},
  author={Jonathan R Wisp{\'e} and Jean C. Clark and B B Warner and D Fajardo and William E. Hull and R B Holtzman and Jeffrey A. Whitsett},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 6},
  pages={1954-60}
}
Tumor necrosis factor-alpha (TNF-alpha) decreased the expression of pulmonary surfactant proteins SP-A and SP-B in human pulmonary adenocarcinoma cell lines. The effect of TNF alpha on SP-A content and mRNA in the pulmonary adenocarcinoma cell line, H441-4, was concentration and time dependent. TNF alpha decreased the cellular content of SP-A to less than… CONTINUE READING