Tumor necrosis factor alpha induces upregulation of CXC-chemokine receptor type II expression and magnifies the proliferative activity of CXC-chemokines in human melanocytes.

@article{Norgauer2003TumorNF,
  title={Tumor necrosis factor alpha induces upregulation of CXC-chemokine receptor type II expression and magnifies the proliferative activity of CXC-chemokines in human melanocytes.},
  author={Johannes Norgauer and Stefan Dichmann and Frank M Peters and Maja Mockenhaupt and Ingrid Schraufst tter and Yared Herouy},
  journal={European journal of dermatology : EJD},
  year={2003},
  volume={13 2},
  pages={124-9}
}
The CXC-chemokines Groalpha and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named CXC-chemokine receptor I & II (CXCRI & II). Both cytokines are potent growth factors for human melanoma cells, with only limited proliferative activity towards normal melanocytes. Here we analysed the influence of various cytokines on the expression of CXCRI & II and the CXC-chemokine-induced proliferation in human melanocytes. Flow cytometric studies revealed no protein… CONTINUE READING

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