Tumor necrosis factor-alpha induces the 85-kDa cytosolic phospholipase A2 gene expression in human bronchial epithelial cells.

@article{Wu1996TumorNF,
  title={Tumor necrosis factor-alpha induces the 85-kDa cytosolic phospholipase A2 gene expression in human bronchial epithelial cells.},
  author={T C Jackson Wu and Tetsuro Ikezono and Craig Angus and James H. Shelhamer},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1310 2},
  pages={175-84}
}
Phospholipase A2 (PLA2) activity has been suggested to mediate some of the tumor necrosis factor (TNF) induced cellular responses including cytotoxicity. We evaluated the induction of both the 85-kDa cytosolic phospholipase A2 (cPLA2) and non-pancreatic group II PLA2 gene expression by TNF-alpha in a human bronchial epithelial cell line (BEAS 2B cell). TNF-alpha (20 ng/ml) induced a significantly increased release of prelabeled [3H]arachidonic acid (AA) following 4-24 h incubation. Calcium… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration.

American journal of physiology. Lung cellular and molecular physiology • 2006
View 2 Excerpts

Metabolic syndrome X is common in Indians: but, why and how?

The Journal of the Association of Physicians of India • 2003

Similar Papers

Loading similar papers…