Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.

@article{Plomgaard2005TumorNF,
  title={Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.},
  author={Peter Plomgaard and Karim Bouzakri and Rikke Krogh-Madsen and Bettina Mittendorfer and Juleen R Zierath and Bente Klarlund Pedersen},
  journal={Diabetes},
  year={2005},
  volume={54 10},
  pages={2939-45}
}
Most lifestyle-related chronic diseases are characterized by low-grade systemic inflammation and insulin resistance. Excessive tumor necrosis factor-alpha (TNF-alpha) concentrations have been implicated in the development of insulin resistance, but direct evidence in humans is lacking. Here, we demonstrate that TNF-alpha infusion in healthy humans induces insulin resistance in skeletal muscle, without effect on endogenous glucose production, as estimated by a combined euglycemic insulin clamp… CONTINUE READING

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