Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

  title={Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.},
  author={T. Folks and K. Clouse and J. Justement and A. Rabson and E. Duh and J. Kehrl and A. Fauci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 7},
  • T. Folks, K. Clouse, +4 authors A. Fauci
  • Published 1989
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin, was demonstrated to induce the expression of human immunodeficiency virus (HIV) in a chronically infected T-cell clone (ACH-2). Concentrations of recombinant TNF-alpha as low as 50 pg/ml induced a significant increase over background of HIV expression in the ACH-2 cells as determined by supernatant reverse transcriptase activity. The HIV-inducing effects of TNF-alpha could not be explained by toxic effects on the cells. In… Expand
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