Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells.

@article{Hanazawa1993TumorNF,
  title={Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells.},
  author={Shigemasa Hanazawa and Akira Takeshita and Shino Amano and Taro Semba and T Nirazuka and Hironori Katoh and Sachie Kitano},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 13},
  pages={9526-32}
}
The mechanism by which circulating monocytes are attracted to sites of bone remodeling is unknown. We now report that tumor necrosis factor-alpha (TNF-alpha), a potent osteotrophic cytokine, was stimulatory for expression of the monocyte chemoattractant JE gene in osteoblastic MC3T3-E1 cells. TNF-alpha stimulated this JE gene expression transcriptionally. The presence of JE gene product in conditioned medium of the cytokine-treated cells was evidenced by an immunoprecipitation assay with… CONTINUE READING

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