Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo.

@article{Ohmori1993TumorNF,
  title={Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo.},
  author={Yoshihiro Ohmori and L. M. Wyner and Shosaku Narumi and David Armstrong and Mark H. Stoler and Thomas A Hamilton},
  journal={The American journal of pathology},
  year={1993},
  volume={142 3},
  pages={861-70}
}
Recombinant murine tumor necrosis factor-alpha (TNF-alpha) was shown to be a strong, systemic stimulus in vivo for members of the chemoattractant cytokine gene families (JE, KC, IP-10). The three genes showed differential sensitivity to TNF-alpha, and their expression demonstrated differential tissue specificity. IP-10 was the most strongly induced messenger RNA and was seen in the liver, kidney, and spleen but very poorly in the lung or skin. JE exhibited a similar pattern, though the… CONTINUE READING

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