Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability.

@article{Paria2004TumorNF,
  title={Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability.},
  author={Biman C. Paria and Stephen M. Vogel and Gias Uddin Ahmmed and Setara Alamgir and Jennifer Shroff and Asrar B. Malik and Chinnaswamy Tiruppath{\`i}},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 6},
  pages={L1303-13}
}
We determined the effects of TNF-alpha on the expression of transient receptor potential channel (TRPC) homologues in human vascular endothelial cells and the consequences of TRPC expression on the endothelial permeability response. We observed that TNF-alpha exposure increased TRPC1 expression without significantly altering expression of other TRPC isoforms in human pulmonary artery endothelial cells (HPAEC). Because TRPC1 belongs to the store-operated cation channel family, we measured the Ca… CONTINUE READING
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