Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death.

@article{SnchezAlczar1997TumorNF,
  title={Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death.},
  author={Jos{\'e} A S{\'a}nchez-Alc{\'a}zar and Jes{\'u}s Ru{\'i}z-Cabello and I Hern{\'a}ndez-Mu{\~n}oz and P S Pobre and Paz de la Torre and Eva Siles-Rivas and Ilda Graciela Fern{\'a}ndez Garc{\'i}a and Ofer Kaplan and Mar{\'i}a Teresa Mu{\~n}oz-Yag{\"u}e and Jos{\'e} Antonio Sol{\'i}s-Herruzo},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 48},
  pages={
          30167-77
        }
}
The effects of tumor necrosis factor-alpha (TNF) on ATP levels were studied in metabolically inhibited L929 cells. Treatment of these cells with TNF in the presence of actinomycin D or cycloheximide induces cyclic changes in the intracellular ATP content preceding cell death. After 3 h of incubation, the intracellular ATP content increased by 48 +/- 6% (p < 0.001), but at 4 h, it decreased to the control level. Two hours later, it increased again by 23 +/- 5% over the control level (p < 0.001… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria

Manuel Oropesa, Mario de la Mata, +7 authors José Antonio Sánchez-Alcázar
  • Apoptosis
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

Update on in vitro cytotoxicity assays for drug development.

  • Expert opinion on drug discovery
  • 2008
VIEW 1 EXCERPT
CITES BACKGROUND