Tumor necrosis factor-alpha in cisplatin nephrotoxicity: a homebred foe?

@article{Dong2007TumorNF,
  title={Tumor necrosis factor-alpha in cisplatin nephrotoxicity: a homebred foe?},
  author={Zheng Dong and Sally S. Atherton},
  journal={Kidney international},
  year={2007},
  volume={72 1},
  pages={5-7}
}
A robust inflammatory response involving tumor necrosis factor-alpha (TNF-alpha) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-alpha. Blockade of TNF-alpha attenuates inflammation and associated kidney injury. 

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