Tumor necrosis factor-alpha gene polymorphism in psoriasis.

  title={Tumor necrosis factor-alpha gene polymorphism in psoriasis.},
  author={Astrid Arias and Belinda Giles and Thomas H. Eiermann and Wolfram Sterry and Janardan P Pandey},
  journal={Experimental and clinical immunogenetics},
  volume={14 2},
Psoriasis, an inflammatory autoimmune disease, is characterized by increased level and activity of the proinflammatory cytokine TNF-alpha in affected lesions. Two promoter region polymorphisms of the TNF-alpha locus--one at position -308 and the other at -238--were examined in 99 Caucasian patients (64 with type I and 35 with type II psoriasis) and in 123 controls. A highly significant difference in the distribution of the -238 polymorphism--the TNF (G,A) genotypes--was detected between the… CONTINUE READING

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