Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.

@article{Chen2003TumorNF,
  title={Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.},
  author={Da Fang Chen and Yonghua Hu and Baiyan Wu and Li Chen and Zhi'an Fang and Fan Yang and Lihua Wang},
  journal={Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences},
  year={2003},
  volume={35 4},
  pages={377-81}
}
OBJECTIVE To investigate the association between polymorphism in tumor necrosis factor-alpha(TNF-alpha)/G308A and preterm delivery (PTD). Between July 1999 and June 2001, we conducted a molecular epidemiological study on genetic determinants of PTD at Anqing Hospital, China. METHODS In a case-control-parent triads study, we investigated a total of 133 nuclear families: 79 normal gestational age families and 54 PTD families. A DNA extraction and polymerase chain reaction followed by… CONTINUE READING