Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.

@article{Ishii2000TumorNF,
  title={Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.},
  author={Tomohiro Ishii and Hiroshi Hirose and Ikuo Saito and Kanako Nishikai and Hiroshi Maruyama and Takao Saruta},
  journal={Metabolism: clinical and experimental},
  year={2000},
  volume={49 12},
  pages={1616-8}
}
In obese subjects, the levels of tumor necrosis factor alpha (TNF-alpha) expression and protein synthesis in adipocytes are increased. A recent study of Caucasians suggested that the TNF-alpha gene promoter region polymorphism at position -308 influences insulin resistance and percent body fat and increases serum leptin levels, although conflicting data are also reported. The present study was performed to investigate the relationship between this polymorphism and the body mass index (BMI… CONTINUE READING
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