Tumor necrosis factor-alpha downregulates the voltage gated outward K+ current in cultured neonatal rat cardiomyocytes: a possible cause of electrical remodeling in diseased hearts.

@article{Kawada2006TumorNF,
  title={Tumor necrosis factor-alpha downregulates the voltage gated outward K+ current in cultured neonatal rat cardiomyocytes: a possible cause of electrical remodeling in diseased hearts.},
  author={Hideaki Kawada and Shinichi Niwano and Hiroe Niwano and Yoshihiro Yumoto and Yuko Wakisaka and Masaru Yuge and Katsumasa Kawahara and Tohru Izumi},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2006},
  volume={70 5},
  pages={605-9}
}
BACKGROUND Inflammatory cytokines have been reported to contribute to the progression of cardiac remodeling in various heart diseases and a remarkable prolongation of the monophasic action potential duration and reductions in the expression of Kv4.2 and K+ channel-interacting protein-2 (KChIP-2) in a rat autoimmune myocarditis model have been documented. In this study, the effect of tumor necrosis factor-alpha (TNF-alpha) on cultured cardiomyocytes was evaluated, focusing on the change in the… CONTINUE READING

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