Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.

  title={Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.},
  author={Ichiro Horie and Mamiko Maeda and Satoshi Yokoyama and Akinori Hisatsune and H. Katsuki and Takeshi Miyata and Yoichiro Isohama},
  journal={Biochemical and biophysical research communications},
  volume={387 3},
Aquaporin-3 (AQP3) is a water/glycerol-transporting protein that is strongly expressed at the plasma membranes of keratinocytes in skin. There is evidence for involvement of AQP3-facilitated water and glycerol transport in skin hydration and wound repair, respectively. In this study, we show that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor-1 signaling decreased AQP3 protein expression and plasma membrane water permeability in DJM-1 keratinocytes. TNF-alpha also decreased AQP3 mRNA… CONTINUE READING


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