Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).

@article{Garton2001TumorNF,
  title={Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).},
  author={Kyle J. Garton and Peter J Gough and Carl P Blobel and Gillian Murphy and David Greaves and Peter J Dempsey and Elaine W. Raines},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 41},
  pages={
          37993-8001
        }
}
Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized with its chemokine domain at the end of a mucin-rich, transmembrane stalk. This membrane-bound localization allows fractalkine to function as an adhesion molecule for cells bearing its receptor, CX3CR1. In addition, fractalkine can be proteolytically released from the cell surface, generating a soluble molecule that functions as a chemoattractant similar to the other members of the chemokine family. In this… CONTINUE READING

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