Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.

@article{Bergmeier2004TumorNF,
  title={Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.},
  author={Wolfgang Bergmeier and Crystal L. Piffath and Guiying Cheng and Vandana S. Dole and Yuhua Zhang and Ulrich H von Andrian and Denisa D Wagner},
  journal={Circulation research},
  year={2004},
  volume={95 7},
  pages={677-83}
}
Interaction of the platelet receptor glycoprotein (GP) Ib-V-IX with von Willebrand factor exposed at a site of vascular injury is an essential step in the initiation of a hemostatic plug. Proteolytic cleavage (shedding) of the GPIbalpha subunit was first described >25 years ago, the protease mediating this event as well as its physiological function, however, have not been elucidated. We reported recently that shedding of GPIbalpha induced by platelet storage or mitochondrial injury involves a… CONTINUE READING
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