Tumor necrosis factor-alpha blockade leads to decreased peripheral T cell reactivity and increased dendritic cell number in peripheral blood of patients with ankylosing spondylitis.

@article{Pang2008TumorNF,
  title={Tumor necrosis factor-alpha blockade leads to decreased peripheral T cell reactivity and increased dendritic cell number in peripheral blood of patients with ankylosing spondylitis.},
  author={Liping Pang and Lisha Wang and Talin Suo and Huiqin Hao and Xianfeng Fang and Junying Jia and Feng Huang and Jie Tang},
  journal={The Journal of rheumatology},
  year={2008},
  volume={35 11},
  pages={2220-8}
}
OBJECTIVE To study the effect of tumor necrosis factor-alpha (TNF-alpha) antagonist (etanercept) treatment on the peripheral T cell reactivity of patients with ankylosing spondylitis (AS). METHODS Peripheral blood mononuclear cells were collected from 40 patients with AS at baseline, after 2 and 6 weeks of etanercept treatment or placebo treatment, and from healthy controls. The number of cells secreting various cytokines was detected by enzyme linked immunospot. Serum soluble interleukin 2… CONTINUE READING

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