Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway.

@article{Srivastava2007TumorNF,
  title={Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway.},
  author={Apurva K. Srivastava and Xuezhong Qin and Nia Wedhas and Marc Arnush and Thomas A. Linkhart and Robert B. Chadwick and Ashok Kumar},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={35113-24}
}
We have investigated the effect of tumor necrosis factor-alpha (TNF-alpha) on the production of extracellular matrix-degrading proteases in skeletal muscles. Using microarray, quantitative PCR, Western blotting, and zymography, we found that TNF-alpha drastically increases the production of matrix metalloproteinase (MMP)-9 from C2C12 myotubes. In vivo administration of TNF-alpha in mice increased the transcript level of MMP-9 in skeletal muscle tissues. Although TNF-alpha activated all the… CONTINUE READING

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