Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis.

@article{Schett2009TumorNF,
  title={Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis.},
  author={Georg Schett and Marina Stolina and Denise Dwyer and Debra Jeske Zack and Stefan Uderhardt and Gerhard Kr{\"o}nke and Paul John Kostenuik and Ulrich Feige},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 9},
  pages={
          2644-54
        }
}
OBJECTIVE To investigate the kinetics of bony spur formation and the relationship of bony spur formation to synovial inflammation and bone erosion in 2 rat arthritis models, and to address whether bony spur formation depends on the expression of tumor necrosis factor alpha (TNFalpha) or RANKL. METHODS Analysis of the kinetics of synovial inflammation, bone erosion, osteoclast formation, and growth of bony spurs was performed in rat collagen-induced arthritis (CIA) and adjuvant-induced… CONTINUE READING
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