Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells.

@article{Brossart2000TumorNF,
  title={Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells.},
  author={Peter Brossart and Anke Zobywalski and Frank Gruenebach and Lars Behnke and Gernot Stuhler and Volker L. Reichardt and Lothar Kanz and W. E. Brugger},
  journal={Cancer research},
  year={2000},
  volume={60 16},
  pages={4485-92}
}
Interleukin (IL)-10 secretion by tumor cells was demonstrated to be one of the mechanisms by which tumor cells can escape immunological recognition and destruction. In dendritic cells (DCs), which are currently used for vaccination therapies for malignant diseases, IL-10 inhibits IL-12 production and induces a state of antigen-specific anergy in CD4- and CD8-positive T cells. We therefore analyzed the effects of different activation stimuli including lipopolysaccharide (LPS), tumor necrosis… CONTINUE READING
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