Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.

@article{Liu1998TumorNF,
  title={Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.},
  author={Li Sen Liu and M. Spelleken and Karin R{\"o}hrig and Hans Hauner and J{\"u}rgen Eckel},
  journal={Diabetes},
  year={1998},
  volume={47 4},
  pages={515-22}
}
Tumor necrosis factor (TNF)-alpha is postulated to play a major role in the pathogenesis of obesity-linked insulin resistance, probably resulting from an interaction with insulin signaling pathways. This cross talk has now been investigated in human adipocytes at the level of phosphatidylinositol (PI) 3-kinase, and the TNF receptors (TNFRs) mediating these processes have been identified. Equilibrium binding studies using human adipocytes from mammary tissue indicated the presence of two… CONTINUE READING