Tumor necrosis factor-alpha (TNF-alpha) in loosening of total hip replacement (THR).

  title={Tumor necrosis factor-alpha (TNF-alpha) in loosening of total hip replacement (THR).},
  author={Jing-wen Xu and Yrj{\"o} T. Konttinen and Jan Lassus and Sirajedin S Natah and A. {\vC}eponis and Svetlana A Solovieva and Per Aspenberg and Seppo Santavirta},
  journal={Clinical and experimental rheumatology},
  volume={14 6},
OBJECTIVE The initially well-fixed implants of total hip replacement (THR) are in the long-term subject to aseptic loosening. Many cytokines can contribute to osteolysis due to osteoclast recruitment and/or activation. However, in this respect tumor necrosis factor-alpha (TNF-alpha) plays a pivotal role, because it upregulates interleukin-1 and 6 and granulocyte-macrophage colony stimulating factor. The aim of this study was to assess the eventual presence, cellular localization and extent of… CONTINUE READING


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