Tumor necrosis factor-alpha (TNF-alpha), interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma) receptors on human normal and scleroderma dermal fibroblasts in vitro.


Interferons alpha and gamma (IFN-alpha, IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) exert different regulatory effects on the proliferation and biosynthetic activities of human dermal fibroblasts. Inasmuch as these cytokines bind to specific receptors in order to exert their activities, the expression of IFN-alpha, IFN-gamma and TNF-alpha… (More)


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