Tumor necrosis factor-alpha: central regulatory cytokine in the induction of macrophage antimicrobial activities.

@article{Nacy1991TumorNF,
  title={Tumor necrosis factor-alpha: central regulatory cytokine in the induction of macrophage antimicrobial activities.},
  author={Carol Ann Nacy and A I Meierovics and Miodrag Belosevic and Sharon J. Green},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={1991},
  volume={59 3},
  pages={
          182-4
        }
}
Expression of activated macrophage resistance to infection requires the cooperative interaction of interferon-gamma (IFN-gamma) and either interleukin-2 (IL-2), interleukin-4 or granulocyte/macrophage-colony-stimulating factor: no single cytokine is effective. For IFN-gamma and IL-2, the effector activity can be suppressed by the presence of anti-tumor necrosis factor-alpha (TNF-alpha) antibodies in the reaction mixture. IFN-gamma and IL-2, only in combination, induce TNF-alpha-specific mRNA… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Drug Resistance in Leishmania Parasites

  • Springer International Publishing
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

The Role of Virus Infection in Deregulating the Cytokine Response to Secondary Bacterial Infection.

  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2015

Similar Papers

Loading similar papers…