Tumor necrosis factor-a (TNF-a) production and localization of macrophages and T lymphocytes in the rabbit corpus luteum.

@article{Bagavandoss1988TumorNF,
  title={Tumor necrosis factor-a (TNF-a) production and localization of macrophages and T lymphocytes in the rabbit corpus luteum.},
  author={P Bagavandoss and Steven L. Kunkel and Roger C. Wiggins and P L Keyes},
  journal={Endocrinology},
  year={1988},
  volume={122 3},
  pages={1185-7}
}
Utilizing immunocytochemistry numerous macrophages were localized in regressing corpora lutea. In contrast, few macrophages were observed in young corpora lutea. Regressing corpora lutea readily produced TNF-a in vitro in response to lipopolysaccharide, whereas young corpora lutea produced significantly less TNF-a. T lymphocytes were identified in young corpora lutea preceding the appearance of macrophages. These observations suggest that cells of the immune system and cytokines could be… CONTINUE READING