Tumor necrosis factor α stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-κB, and nuclear receptors PPARα and LXRs

@article{Shavva2018TumorNF,
  title={Tumor necrosis factor α stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-κB, and nuclear receptors PPARα and LXRs},
  author={Vladimir S. Shavva and Denis A. Mogilenko and Ekaterina V. Nekrasova and Andrey S. Trulioff and Igor V Kudriavtsev and Ekaterina E. Larionova and Anna V. Babina and Ella B. Dizhe and Boris V Missyul and Sergey V Orlov},
  journal={Molecular and Cellular Biochemistry},
  year={2018},
  volume={448},
  pages={211-223}
}
Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. ApoA-I has been shown to regulate lipid metabolism and inflammation in macrophages. Recently, we found the moderate expression of endogenous apoA-I in human monocytes and macrophages and showed that pro-inflammatory cytokine tumor necrosis factor α (TNFα) increases apoA-I mRNA and stimulates ApoA-I protein secretion by human monocytes and macrophages. Here, we present data about… CONTINUE READING
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