Tumor necrosis factor-α induces transcriptional activation of nuclear factor-κB in insulin-producing β-cells.

  • Jai Parkash
  • Published 2011 in Experimental and therapeutic medicine

Abstract

We previously showed that tumor necrosis factor-α (TNF-α) induces the dysregulation of intracellular calcium [Ca(2+)](i) in β-cells by decreasing the levels of the cytoplasmic Ca(2+) binding protein calbindin-D(28k). The purpose of the present study was to test the hypothesis that TNF-α-induced dysregulation of [Ca(2+)](i) in insulin-producing β-cells… (More)

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@article{Parkash2011TumorNF, title={Tumor necrosis factor-α induces transcriptional activation of nuclear factor-κB in insulin-producing β-cells.}, author={Jai Parkash}, journal={Experimental and therapeutic medicine}, year={2011}, volume={2 1}, pages={21-26} }