Tumor necrosis factor-α induces renal vasoconstriction as well as natriuresis in mice

  title={Tumor necrosis factor-α induces renal vasoconstriction as well as natriuresis in mice},
  author={Mohd Shahid and Joseph Francis and Dewan Syed Abdul Majid},
  journal={American Journal of Physiology - Renal Physiology},
  pages={F1836 - F1844}
Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of hypertension and renal injury. However, the direct effects of TNF-alpha on renal hemodynamic and excretory function are not yet clearly defined. We examined the renal responses to infusion of TNF-alpha (0.33 ng.g(-1).min(-1)) in anesthetized mice. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by PAH and inulin clearance. The urine was collected from a cannula inserted into the… CONTINUE READING


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