Tumor necrosis factor-α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure.

@article{Wang2011TumorNF,
  title={Tumor necrosis factor-α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure.},
  author={Wen Wang and Sa Lv and Ying Zhou and Jinlong Fu and Chengbo Li and Pei Liu},
  journal={European journal of gastroenterology & hepatology},
  year={2011},
  volume={23 7},
  pages={552-8}
}
OBJECTIVES Cerebral edema is a major cause of death during acute liver failure (ALF), but the exact mechanism of this condition is still not entirely clear. The aim of this study was to investigate the role of tumor necrosis factor α (TNFα) in changing the permeability of the blood-brain barrier (BBB) during acetaminophen (APAP)-induced ALF. MATERIALS AND METHODS ALF animal models were generated by administering APAP. Anti-TNFα-IgG was intravenously injected (100 μg/mouse) 2 h after… CONTINUE READING

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