Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis.

@article{Kwon2013TumorNF,
  title={Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis.},
  author={Yang Woo Kwon and Soon Chul Heo and Geun Ok Jeong and Jung Won Yoon and Won Min Mo and Mi Jeong Lee and Il-ho Jang and Sang-Mo Kwon and Jung Sub Lee and Jae Ho Kim},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 12},
  pages={2136-44}
}
Mesenchymal stem cells (MSCs) accelerate regeneration of ischemic or injured tissues by stimulation of angiogenesis through a paracrine mechanism. Tumor necrosis factor-α (TNF-α)-activated MSCs secrete pro-angiogenic cytokines, including IL-6 and IL-8. In the present study, using an ischemic hindlimb animal model, we explored the role of IL-6 and IL-8 in the paracrine stimulation of angiogenesis and tissue regeneration by TNF-α-activated MSCs. Intramuscular injection of conditioned medium… CONTINUE READING
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